Neutrophil Lymphocyte Ratio in Different Types of Glaucoma
Sedat ARIKAN1, İsmail ERŞAN1, Selçuk KARA1, Hasan Ali TUFAN1, Ömer KOCABIYIK2, Baran GENCER1, Yusuf Haydar ERTEKİN3
1M.D. Asistant Professor, Canakkale Onsekiz Mart University School of Medicine, Department of Ophthalmology, Canakkale/TURKEY 2M.D. Asistant, Canakkale Onsekiz Mart University School of Medicine, Department of Ophthalmology, Canakkale/TURKEY 3M.D. Asistant Professor, Canakkale Onsekiz Mart University School of Medicine, Department of Family Medicine, Canakkale/TURKEY
Purpose: To evaluate the neutrophil-lymphocyte ratio (NLR) in patients with primary open angle glaucoma (POAG), and pseudoexfoliative
Material and Methods: A total 120 subjects consisted of 40 POAG patients (Group 1), 40 PEG patients (Group 2), and 40 age and sex matched
non-glaucoma subjects (Group 3) were included in this retrospective study. The NLR calculation was made according to division of neutrophil
numbers to lymphocyte numbers that were obtained from medical records of the subjects. The correlation between NLR and retinal nerve fiber
layer (RNFL) thickness was also evaluated in all groups.
Results: The mean NLR values in Group 1, Group 2, and Group 3 was respectively as 2.3±0.2, 2.9±0.3, and 1.7±0. A significant difference was
determined between Group 1 and Group 3 (p=0.012), also between Group 2 and Group 3 (p=0.001), with regard to mean NLR value. However,
no significant difference was determined between Group 1 and Group 2 in mean NLR value (p=0.1). Additionally NLR was not found to be
correlated with thinning in the RNFL.
Conclusions: The high NLR ratio may likely support the role of oxidative stress and inflammation in the development of glaucoma, especially
in PEG patients.