Effect of Prostaglandin Analogue Medications on Thickness of Corneal Epithelium and Stroma
Sedat ARIKAN1, Selçuk KARA1, İsmail ERŞAN1, Baran GENCER1, Hasan Ali TUFAN2, Arzu TAŞKIRAN ÇÖMEZ2
1M.D. Assistant Professor, Department of Ophthalmology, Canakkale Onsekiz Mart University School of Medicine, Canakkale/TURKEY 2M.D. Associate Professor, Department of Ophthalmology, Canakkale Onsekiz Mart University School of Medicine, Canakkale/TURKEY
Purpose: To evaluate the effect of prostaglandin analogues (PGAs) used in one eye drop, or in combination with other anti-glaucoma eye drops
on the thickness of corneal epithelium and stroma.
Materials and Methods: A total 82 eyes of 59 patients were included into this retrospective study. The glaucoma patients and glaucoma-suspected
individuals, who had the values of corneal thickness measured by anterior segment optical coherence tomography (AS-OCT) in their medical records,
were assigned to three groups. Group 1 involved the glaucoma patients who were receiving only one anti-glaucoma eye drop which contains
either only one of the three PGAs (latanoprost 0.005%, travoprost 0.004%, or bimatoprost 0.03%), or a combination of one of those with timolol.
Group 2 involved the glaucoma patients who were receiving more than one anti-glaucoma eye drop, provided that one of them should contain any
of the PGAs. Group 3 involved the glaucoma-suspected individuals who were not receiving any anti-glaucoma eye drop.
Results: The mean thickness of the corneal epithelium was significantly thinner in Group 1 and Group 2 [(56±3.1 μm in Group 1 vs.
61.2±2.1 μm in Group 3, p<0.001), (56.3±2.8 μm in Group 2 vs. 61.2±2.1 μm in Group 3, p<0.001)]. On the other hand, the mean thickness
of corneal stroma was only significantly thinner in Group 2 [(448±40 μm in Group 2 vs.496±40 μm in Group 3, p<0.001), (448±40 μm in
Group 2 vs. 486±30 μm in Group 1, p=0.001)].
Conclusions: The PGAs can reduce corneal epithelial thickness when they are used in one eye drop, or in combination with the other anti-glaucoma
eye drops. However, corneal stromal thinning may appear in case of PGAs are used in combination with other anti-glaucoma eye drops.