TJ-CEO
2010 , Vol 5 , Num 1
Effectiveness of Latanoprost %0.005 and Timolol Maleat %0.5 Fixed Combination in Patients with Primary Open-Angle Glaucoma
1Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Göz Hastalıkları, İstanbul, Uz. Dr.2Kilis Devlet Hastanesi, Göz Hastalıkları, Kilis, Uzl. Dr.
3Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Göz Hastalıkları, İstanbul, Prof. Dr. Purpose: To evaluate the intraocular pressure (IOP) lowering effect, diurnal variation and adverse effects of Latanoprost %0.005 and Timolol Maleat %0.5 fixed combination (LTFC) in patients with Primary Open-Angle Glaucoma (POAG)
Materials and Methods: In this prospective study,112 eyes of 56 patients with the diagnosis of POAG who haven't received any glaucoma medication were included. This group was treated with LTFC for 6 months.
Results: Pre and 6th month IOP was; 23.70±1.70 mmHg and 14.42±1.78 mmHg respectively. After 6 months of treatment the reduction of IOP was statistically significant. Compared with pre-treatment, at 3rd month diurnal variation was significantly lower (p<0.01). Systemic adverse effect was not observed in any patients. Mild and moderate conjunktival hyperemia was observed in 17 eyes, ocular irritation was observed in 20 eyes, ocular pain observed in 2 eyes, hypertrichosis observed in 8 eyes.
Conclusion: In patients with POAG LTFC is effective and safe treatment for reducing IOP. Keywords : Latanoprost-timolol maleat, ıntraocular pressure, diurnal variation of intraocular pressure