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¹Beyoğlu Göz Eğitim ve Araştırma Hastanesi, İstanbul, Uzm. Dr.
²Beyoğlu Göz Eğitim ve Araştırma Hastanesi, İstanbul, Prof. Dr.
³Serbest hekim, İstanbul, Uz. Dr.
⁴Kilis Devlet Hastanesi, Gaziantep, Uz. Dr. Purpose: Latanoprost has effects on extracellular matrix and collagen metabolism in the ciliary body. The same mechanisms probably act in cornea, zonula fibers and sclera. The aim of the current study was to analyze the clinical visible effects latanoprost on axial length (AL), anterior chamber depth (ACD), corneal topography, endothelial cell density (ECD) and central corneal thickness (CCT).
Materials and Methods: Fifty-four eyes of 54 patients with newly diagnosed primary open angle glaucoma, normotensive glaucoma or ocular hypertension were included. Patients were examined before treatment and at the first, third and sixth month after latanoprost treatment. Visual acuity (VA), spheric equıvalent (SE), intraocular pressure (IOP), AL, ACD, corneal topography, ECD, and CCT were measured at each examination.
Results: Twenty-one males and 33 females with a mean age of 59.2±12.6 years were included in the study. The mean IOP which was 21.4±7.2 mmHg before therapy significantly decreased to 14.6±4.6 mmHg at the first month, 14.9±3.6 mmHg at the third month and 14.7±3.5 mmHg at the sixth month (p<0.001). A significant positive correlation was found between baseline IOP and IOP-lowering effect and a negative correlation was present between IOP-lowering effect and AL (p<0.05). No significant change in VA and SE was found after treatment. No significant change was observed in AL, ACD, ECD, and corneal topography parameters (p>0.05). A statistically significant reduction in CCT was observed within 6 months (p=0.03).
Conclusion: Although latanoprost 0.005% does not cause clinically detectable changes in corneal topography, ECD, ACD and AL, it only causes statistically significant reduction in central corneal thickness within 6 months of the treatment period. Further large-scale studies with longer follow-ups are needed to elucidate effects of latanoprost on ocular structures. Keywords : Latanoprost, axial length, anterior chamber depth, corneal topography, endothelial cell density and central corneal thickness